基本情况

姓名：毛宗万

性别：男

出生年月：1962-07

职位：线上赌博app-赌博软件下载 教授、博士生导师。

研究方向：金属诊疗化学生物学，金属配位与核酸化学，金属蛋白（酶）化学生物学，细胞无机化学生物学。

联系方式

电话：+86 20 3106 8337

邮箱：[email protected]

通讯地址：广州市番禺区大学城外环东路132号中山大学广州校区东校园化材大楼

邮编：510006

个人网站：//xsdbapp.com/zh-hans/teacher/809（中文）

                  //xsdbapp.com/en/teacher/8398（EN）

 

个人荣誉和奖励

中山大学逸仙领军学者，国家杰出青年科学基金获得者，中国化学会会士，英国皇家化学会会士，享受国务院政府津贴。获中山大学许崇清教学奖，第三届中山大学芙兰奖，第十三届广东省丁颖科技奖，南粤优秀教师，广东省教学名师，宝钢优秀教师奖和特等奖提名奖，入选百名南粤杰出人才培养工程。

教育经历

1982年：获四川大学学士学位

1991年：获南京大学硕士学位 （导师：唐雯霞教授）

1994年：获南京大学博士学位（导师：唐雯霞教授） 

1995-1996年：中山大学博士后研究（合作导师：计亮年院士） 

1997-1998年：德国埃尔兰根-纽伦堡大学洪堡访问学者（合作导师：Rudi van Eldik教授）

工作经历

1982-1988年期间曾在绵阳师范学院和西华师范大学工作，现为线上赌博app-赌博软件下载 教授，博士生导师。

教学情况

“国家级教学团队”主要成员，国家精品课程《综合化学实验》课程负责人。先后讲授《无机化学》、《配位化学与生物无机化学》、《综合化学实验》、《现代化学研究方法与技术》等课程，主编《综合化学实验》、《生物无机化学导论》（现代化学基础丛书）等本科生和研究生教材著作。主持多项省级大学化学实验教学研究及改革项目，在《中国大学教学》、《大学化学》等刊物上发表教学研究论文10余篇，担任2004年国际化学奥林匹克竞赛中国队教练，主持广东省中学化学教材改革项目。教改研究与人才培养获省级教学成果奖5项、国家级1项，其中以第一完成人获国家教学成果二等奖。

科研情况

长期从事生物无机化学和金属化学生物学研究，主要包括金属诊疗、金属酶化学、核酸化学、药物化学生物学、分子探针、生物成像等，先后承担国家杰出青年基金项目、国家基金集成/重大/重点/面上项目、教育部创新团队、广东省创新团队、科技部973和国家重点研究计划课题等，已在在Nat. Chem. Bio., Nat. Commun.，J. Am. Chem. Soc., Angew. Chem. Int. Ed.，Natl. Sci. Rev.等杂志发表论文240余篇，H-index = 68，获国家发明专利9 件，国际PCT专利3件。编写英文专著章节3部，研究成果获省部级奖励2项、国家级1项，其中以第一完成人获国家自然科学奖二等奖。

国家级成果奖

1、“金属酶的化学模拟及其构效关系研究”获2012年国家自然科学二等奖（第一完成人）
2、“新时期化学创新人才培养模式的探索与实践”获2018年国家教学成果二等奖（第一完成人）

社会服务

曾任中山大学化学化工学院院长（2010-2016）、线上赌博app 院长（2016-2018）。现任中国化学会理事、中国化学会无机化学学科委员会副主任、化学生物学学科委员会副主任、广东省化学学会理事长。目前担任J. Inorg. Biochem.、《高等学校化学学报》、《无机化学》等杂志编委，Isabc、EuAsC2S国际顾委。

主持项目（在研）

1、国家基金重大研究计划集成项目：新技术新方法驱动金属介导的生物大分子动态修饰研究
2、国家基金重大项目课题：金属免疫相关的靶向干预新手段
3、国家重点研究计划课题：病灶微环境响应催化材料的生物学效应及构效关系

论著一览（近5年代表性论文）

  1. K. Lu, B. Luo, X. Tao, Y. Luo, M. Ao, B. Zheng, X. Xu, X. Ma, J. Niu, H. Li, Y. Xie, Z. Zhao, P. Zheng, G. Wang, S. Gao, C. Wang, W. Xia*, Z. Su*, Z.-W. Mao*. Complex structure and activation mechanism of arginine kinase McsB by McsA. Nat. Chem. Bio. 2024, accepted. DOI: 10.1038/s41589-024-01720-3.
  2. Y.-L- Zeng, L.-Y. Liu*, T.-Z. Ma, Y. Liu, B. Liu, W. Liu, Q.-H. Shen, C. Wu, Z.-W. Mao*. Iridium (III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi‐Network Synergistic Tumor Immunotherapy. Angew. Chem. Int. Ed. 2024, 63, e202410803. DOI: 10.1002/ange.202410803.
  3. B Liu, B.-B. Liang, W.-D. Cao, X.-X. Su, Q. Cao*, Z.-W. Mao*. Platinum‐Metformin Conjugates Acting as Promising PD‐L1 Inhibitors through the AMP‐Activated Protein Kinase Mediated Lysosomal Degradation Pathway, Angew. Chem. Int. Ed.2024, 63, e202410586.DOI: 10.1002/ange.202410586.
  4. W Liu, B.-C. Zhu, L.-Y. Liu, X.-Y. Xia, J. Jang, J. Dickerhoff, D. Yang*, Z.-W. Mao*. Solution structures and effects of a platinum compound successively bound MYC G-quadruplex. Nucleic Acids Res. 2024, 52, 9397. DOI: 10.1093/nar/gkae649.
  5. T.-Z. Ma, L.-Y. Liu, Y.-L. Zeng, K. Ding, H. Zhang, W. Liu*, Q. Cao, W. Xia, X. Xiong*, C. Wu*, Z.-W. Mao*. G-quadruplex-guided cisplatin triggers multiple pathways in targeted chemotherapy and immunotherapy. Chem. Sci. 2024, 15, 9756. DOI: 10.1039/D4SC00643G.
  6. M. Lv, C. Wu*, H.-K. Liu*, X Xue*, Z.-W. Mao*. Ruthenium(ii)–Arene Complex Triggers Immunogenic Ferroptosis for Reversing Drug Resistance. J. Med. Chem. 2024, accepted. DOI: 10.1021/acs.jmedchem.4c01467.
  7. Y. Li*, B. Liu, Y. Zheng, M. Hu, L.-Y. Liu, C.-R. Li, W. Zhang*, Y.-X. Lai*, Z.-W. Mao*. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy. J. Med. Chem. 2024, 67, 18, 16235-16247
  8. W.-J. Wang#, Y.-Y. Ling#, Y. Shi#, X.-W. Wu, X. Su, Z.-Q. Li*, Z.-W. Mao*, C.-P. Tan*. Identification of mitochondrial ATP synthase as the cellular target of Ru-polypyridyl-β-carboline complexes by affinity-based protein profiling. Natl. Sci. Rev. 2024, 11, nwae234
  9. Q. Chen#, L.-Y. Liu#, Z. Tian#, Z. Fang#, K.-N. Wang, X. Shao, C. Zhang, W. Zou, F. Rowan, K. Qiu, B. Ji, J.-L. Guan, D. Li, Z.W. Mao*, J. Diao*. Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature. Cell Rep. 2023, 42(12), 113472. DOI: 10.1016/j.celrep.2023.113472.
  10. Y. Ai, Z. Zhang, Y. Fei, R. Ye, A.S.Y. Law, Z.-W. Mao*, J. Liu*, Y. Li*, VW.W. Yam*. Rational design of platinum(II) complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo. Sci. China Chem. 2023, 66, 2878. DOI: 10.1007/s11426-023-1702-x.
  11. M. Lv#, Y. Zheng#, J. Wu, Z. Shen, B. Guo, G. Hu, Y. Huang, J. Zhao, Y. Qian, Z. Su, C. Wu*, X. Xue*, H.-K. Liu*, Z.W. Mao*. Evoking Ferroptosis by Synergistic Enhancement of a Cyclopentadienyl Iridium-Betulin Immune Agonist. Angew. Chem. Int. Ed. 2023, 62(48), e202312897. DOI: 10.1002/anie.202312897. 
  12. B.-B. Liang#, Q. Liu#, B. Liu, H.-G. Yao, J. He, C.-F. Tang, K. Peng, X.-X. Su, Y. Zheng, J.-Y. Ding, J. Shen*, Q. Cao*, Z.W. Mao*. A Golgi-Targeted Platinum Complex Plays a Dual Role in Autophagy Regulation for Highly Efficient Cancer Therapy. Angew. Chem. Int. Ed. 2023, 62(44), e202312170. DOI: 10.1002/anie.202312170. 
  13. W. Lin#, Y. Liu#, J. Wang, Z. Zhao, K. Lu, H. Meng, R. Luoliu, X. He, J. Shen*, Z.W. Mao*, W. Xia*. Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors. Angew. Chem. Int. Ed. 2023, 62(43), e202310158. DOI: 10.1002/anie.202310158. 
  14. L.-Y. Liu#, T.-Z. Ma, Y.-L. Zeng, W. Liu, H. Zhang, Z.W. Mao*. Organic-Platinum Hybrids for Covalent Binding of G-Quadruplexes: Structural Basis and Application to Cancer Immunotherapy. Angew. Chem. Int. Ed. 2023, 62(36), e202305645. DOI: 10.1002/anie.202305645.
  15. Z. Zhao#, X. Wang#, J. Wang#, Y. Li#, W. Lin, K. Lu, J. Chen, W. Xia*, Z.-W. Mao*. A nanobody–bioorthogonal catalyst conjugate triggers spatially confined prodrug activation for combinational chemo-immunotherapy. J. Med. Chem. 2023, 66, 11951-11964
  16. Y. Zheng#, X.-X. Chen#, D.-Y. Zhang, W.-J. Wang, K. Peng, Z.-Y. Li, Z.W. Mao*, C.-P. Tan*. Activation of the cGAS-STING pathway by a mitochondrial DNA-targeted emissive rhodium(iii) metallointercalator. Chem. Sci. 2023, 14(25), 6890-6903. DOI: 10.1039/d3sc01737k. 
  17. W.-J. Wang#, C.-P. Tan*, Z.W. Mao*. Metals and inorganic molecules in regulating protein and nucleic acid phase separation. Curr. Opin. Chem. Biol. 2023, 74, 102308. DOI: 10.1016/j.cbpa.2023.102308. 
  18. K. Peng#, Y. Zheng#, W. Xia*, Z.W. Mao. Organometallic Anti-tumor Agents: Targeting from Biomolecules to Dynamic Bioprocesses. Chem. Soc. Rev. 2023, 52, 2790-2832. DOI: 10.1039/d2cs00757f.
  19. X. Su, B. Liu, W. J. Wang, K. Peng, B.B. Liang, Y. Zheng, Q. Cao*, Z.W. Mao*. Disruption of Zinc Homeostasis by a Novel Platinum(IV)-Terthiophene Complex for Antitumor Immunity. Angew. Chem. Int. Ed. 2023, 62, e202216917. DOI: 10.1002/anie.202216917.
  20. L.Y. Liu, T.Z. Ma, Y.L. Zeng, W. Liu*, Z.W. Mao*. Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes. J. Am. Chem. Soc., 2022, 144, 11878-11887. DOI: 10.1021/jacs.2c04775.
  21. Z. Zhao, X. Tao, Y. Xie, Q. Lai, Y. Zheng, W. Lin, K. Lu, J. Wang, W. Xia*, Z.W. Mao*, In Situ Prodrug Activation by an Affibody-ruthenium Catalyst Hybrid for HER2-targeted Chemotherapy. Angew. Chem. Int. Ed. 2022, 61, e202202855. DOI: 10.1002/anie.202202855.
  22. W.J. Wang, Y.Y. Ling, Y.M. Zhong, Z.Y. Li, C.P. Tan*, Z.W. Mao*. Ferroptosis-enhanced Cancer Immunity by a Ferrocene-appended Iridium(III) Diphosphine Complex. Angew. Chem. Int. Ed. 2022, e202115247. DOI: 10.1002/anie.202115247.
  23. X. Su, W.J. Wang, Q. Cao*, H. Zhang, B. Liu, Y. Ling, X. Zhou, Z.W. Mao*. A Carbonic Anhydrase IX(CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-tumor Immunity. Angew. Chem. Int. Ed. 2022, 61, e202115800. DOI: 10.1002/anie.202115800.
  24. Y.Y. Ling, X.Y. Xia, L. Hao, W.J. Wang, H. Zhang, L.Y. Liu, W. Liu, Z.Y. Li, C.P. Tan*, Z.W. Mao*. Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Pt(II)-triphenylamine Complexes for Cancer Immunotherapy. Angew. Chem. Int. Ed. 2022, e202210988. DOI: 10.1002/anie.202210988.
  25. K.N. Wang, L.Y. Liu, D. Mao, M.X. Hou, C.P. Tan, Z.W. Mao*, B. Liu*. A Nuclear-Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation. Angew. Chem. Int. Ed. 2022, 61, e202114600. DOI: 10.1002/anie.202114600.
  26. B.C. Zhu, J. He, X.Y. Xia, J. Jiang, W. Liu, L.Y. Liu, B.B. Liang, H.G. Yao, Z. Ke*, W. Xia*, Z.W. Mao*. Solution Structure of a Thrombin Binding Aptamer Complex with a Non-planar Platinum(II) Compound. Chem. Sci. 2022, 13, 8371-8379. DOI: 10.1039/D2SC01196D.
  27. G.G. Yang, X.X. Su, B.B. Liang, Z.Y. Pan, Q. Cao*. Z.W. Mao*. Platinum-Ruthenium Hybrid Prodrug with Multi-enzymatic Activities for Chemo-catalytic Therapy of Hypoxic Tumors. Chem. Sci. 2022, 13, 11360-11367. DOI: 10.1039/D2SC03375E.
  28. L. Hao, Y.Y. Ling, Z.X. Huang, Z.Y. Pan, C.P. Tan*, Z.W. Mao*. Real-time Tracking of ER Turnover during ERLAD by a Rhenium Complex via Lifetime Imaging. Natl. Sci. Rev. 2022, 9, nwab194. DOI: 10.1093/nsr/nwab194/6413567.
  29. W.J. Wang, X. Mu, C.P. Tan*, Y.J. Wang, Y. Zhang*, G. Li*, Z.W. Mao*. Induction and Monitoring of DNA Phase Separation in Living Cells by a Light-Switching Ruthenium Complex. J. Am. Chem. Soc. 2021, 143, 11370-11381. DOI: 10.1021/jacs.1c01424.
  30. B.C. Zhu, J. He, W. Liu*, X.Y. Xia, L.Y. Liu, B.B. Liang, H.G. Yao, B. Liu, L.N. Ji, Z.W. Mao*. Selectivity and Targeting of G-quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics. Angew. Chem. Int. Ed. 2021, 60, 15340-15343. DOI: 10.1002/anie.202104624.
  31. L.Y. Liu, K.N. Wang, W. Liu*, Y.L. Zeng, M.X. Hou, J. Yang, Z.W. Mao*. Spatial Matching Selectivity and Solution Structure of Organic-Metal Hybrid to Quadruplex-Duplex Hybrid. Angew. Chem. Int. Ed. 2021, 60, 20833-20839. DOI: 10.1002/anie.202106256.
  32. K. Peng, B.B. Liang, W. Liu, Z.W. Mao*. What Blocks More Anticancer Platinum Complexes From Experiment to Clinic: Major Problems and Potential Strategies from Drug Design Perspectives. Coord. Chem. Rev. 2021, 449, 214210. DOI: 10.1016/j.ccr.2021.214210.
  33. X. Tao, L. Zhang, L. Du, R. Liao, H. Cai, K. Lu, Z. Zhao, Y. Xie, P.H. Wang, J.A. Pan, Y. Zhang, G. Li, J. Dai, Z.W. Mao*, W. Xia*. Allosteric Inhibition of SARS-CoV-2 3CL Protease by Colloidal Bismuth Subcitrate. Chem. Sci. 2021, 12, 14098-14102. DOI: 10.1039/D1SC03526F.
  34. C.P. Tan*, Y.M. Zhong, L.N. Ji, Z.W. Mao*, Phosphorescent metal complexes as theranostic anticancer agents: combining imaging and therapy in a single molecule. Chem. Sci. 2021, 12, 2357-2367. DOI: 10.1039/d0sc06885c.
  35. K.N. Wang, X. Shao, Z. Tian, L.Y. Liu, C. Zhang, C.P. Tan, J. Zhang, P. Ling, F. Liu, Q. Chen, J. Diao*, Z.W. Mao*. A Continuous Add-on Probe Reveals the Nonlinear Enlargement of Mitochondria in Light-Activated Oncosis. Adv. Sci. 2021, 8, 2004566. DOI: 10.1002/advs.202004566.
  36. Y. Zheng, Y. Ling, D.Y. Zhang, C.P. Tan*, H. Zhang, G.G. Yang, H. Wang, L.N. Ji, Z.W. Mao*. Regulating Tumor N6-methyladenosine Methylation Landscape Using Hypoxia-Modulating OsSx Nanoparticles. Small, 2021, 17(1), 2005086. DOI: 10.1002/smll.202005086.
  37. F.X. Wang, J.W. Liu, X.Q. Hong, C.P. Tan, L. Zhang*, W.H. Chen*, P. Sadler*, Z.W. Mao*. Anion-responsive Manganese Porphyrin Facilitates Chloride Transport and Induces Immunogenic Cell Death. CCS Chem. 2021, 3, 2527-2537. DOI:10.31635/ccschem. 021.202101212.
  38. Q. Cao, D.J. Zhou, Z.Y. Pan, G.G. Yang, H. Zhang, L.N. Ji, Z.W. Mao*. CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors, Angew. Chem. Int. Ed. 2020, 59, 18556−18562. DOI: 10.1002/anie.202005362.
  39. L.Y. Liu, H. Fang, Q. Chen, M.H. Chan, M. Ng, K.N. Wang, W. Liu, Z. Tian, J. Diao*, Z.W. Mao*, V.W. Yam*. Multiple-color Platinum Complex with Super-large Stokes Shift for Super-resolution Imaging of Autolysosome Escape, Angew. Chem. Int. Ed. 2020, 59, 19229−19236. DOI: 10.1002/anie.202007878.
  40. L.Y. Liu, W. Liu, K.N. Wang, B.C. Zhu, X.Y. Xia, L.N. Ji, Z.W. Mao*, Quantitative Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination. Angew. Chem. Int. Ed. 2020, 59, 9719−9726. DOI: 10.1002/anie.202002422.
  41. Z.Y. Pan, C.P. Tan*, L.S. Rao, H. Z., Y. Zheng, L. Hao, L.N. Ji, Z.W. Mao*, Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria-Targeted Rhenium(I) Complexes, Angew. Chem. Int. Ed., 2020,59, 2−10. DOI: 10.1002/anie.202008624.
  42. J.H. Liang, Y. Zheng, X.W. Wu, C.P. Tan*, L.N. Ji, Z.W. Mao*. A Tailored Multifunctional Anticancer Nanodelivery System for Ruthenium-based Photosensitizers: Tumor Microenvironment Adaption and Remodeling. Adv. Sci. 2020, 7, 1901992. DOI: 10.1002/advs.201901992.