基本情况
姓名:刘文婷
性别:女
出生年月:1990-09
籍贯:广东兴宁
职位:副教授,硕士生导师
联系方式
通讯地址:广州市大学城外环东路132号中山大学化学材料综合楼
邮编:510006
教育经历
2013.09-2018.06:中山大学,线上赌博app ,博士
2014.10-2016.10:美国亚利桑那大学/普渡大学,药学院,联合培养博士
2009.09-2013.06:中山大学,化学与化学工程学院,学士
工作经历
2024.04-至 今:副教授,线上赌博app-赌博软件下载
2019.09-2024.03:特聘副研究员,线上赌博app-赌博软件下载
2018.08-2021.08:博士后,线上赌博app-赌博软件下载
科研方向
主要从事核酸化学生物学、金属化学生物学和生物核磁共振技术研究。
1. 核酸四链体的识别、靶向、活细胞探测与功能调控;
2. 靶向/响应型金属配合物及其生物成像、抗肿瘤/衰老机制;
3. 发展并利用生物核磁共振技术阐明作用机制、动态变化与构效关系。
科研项目
1. 国家自然科学基金优秀青年项目,2025.01-2027.12,主持
2. 广东省自然科学基金杰出青年项目,2024.01-2027.12,主持
3. 国家自然科学基金面上项目,2023.01-2026.12,主持
4. 国家自然科学基金青年项目,2021.01-2023.12,主持
5. 广东省自然科学基金面上项目,2019.10-2022.09,主持
6. 广州市科技计划博士青年科技项目,2023.04-2025-03,主持
7. 高校基本科研业务费中山大学青年教师培育项目,2020.01-2022.12,主持
获奖情况
1. 国家优青(2024)
2. 广东省杰青(2023)
主要论著
- W. Liu, B.-C. Zhu, L.-Y. Liu, X.-Y. Xia, J. Jang, J. Dickerhoff, D. Yang*, Z.-W. Mao*. Solution Structures and Effects of a Platinum Compound Successively Bound MYC G-quadruplex. Nucleic Acids Res. 2024, 52(16), 9397-9406. DOI: 10.1093/nar/gkae649.
- T.-Z. Ma, L.-Y. Liu, Y.-L. Zeng, K. Ding, H. Zhang, W. Liu*, Q. Cao, W. Xia, X. Xiong*, C. Wu*, Z.-W. Mao*, G-quadruplex-Guided Cisplatin Triggers Multiple Pathways in Targeted Chemotherapy and Immunotherapy. Chem. Sci. 2024, 15(25), 9756-9774. DOI: 10.1039/D4SC00643G.
- L.-S. Rao, L. Hao, L.-Y. Liu, Y.-L. Zeng, B.-B. Liang, W. Liu*, Z.-W. Mao*, Detection and Tracking of Cytoplasmic G-quadruplexes in Live Cells. Chem Commun. 2023, 59(89), 13348-13351. DOI: 10.1039/d3cc03043a.
- L.-Y. Liu, T.-Z. Ma, Y.-L. Zeng, W. Liu*, Z.-W. Mao*, Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-quadruplexes. J. Am. Chem. Soc. 2022, 144(26), 11878-11887. DOI: 10.1021/jacs.2c04775.
- B.-C. Zhu#, J. He#, X.-Y. Xia#, J. Jiang, W. Liu*, L.-Y. Liu, B.-B. Liang, H.-G. Yao, Z. Ke*, W. Xia*, Z.-W. Mao*, Solution Structure of a Thrombin Binding Aptamer Complex with a Non-Planar Platinum(II) Compound. Chem. Sci. 2022, 13(28), 8371-8379. DOI: 10.1039/D2SC01196D.
- L.-Y. Liu, K.-N. Wang, W. Liu*, Y.-L. Zeng, M.-X. Hou, J. Yang, Z.-W. Mao*, Spatial Matching Selectivity and Solution Structure of Organic-Metal Hybrid to Quadruplex-Duplex Hybrid. Angew. Chem. Int. Ed. 2021, 60(38), 20833-20839. DOI: 10.1002/anie.202106256.
- B.-C. Zhu, J. He, W. Liu*, X.-Y. Xia, L.-Y. Liu, B.-B. Liang, H.-G. Yao, B. Liu, L.-N. Ji, Z.-W. Mao*, Selectivity and Targeting of G-quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics. Angew. Chem. Int. Ed.2021, 60(28), 15340-15343. DOI: 10.1002/anie.202104624.
- L.-Y. Liu#, W. Liu#, K.-N. Wang, B.-C. Zhu, X.-Y. Xia, L.-N. Ji, Z.-W. Mao*, Quantitative Detection of G-quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination. Angew. Chem. Int. Ed.2020, 59(24), 9719-9726. DOI: 10.1002/anie.202002422.
- W. Liu, C. Lin, G. Wu, J. Dai, T.-C. Chang, D. Yang*, Structures of 1:1 and 2:1 Complexes of BMVC and MYC Promoter G-quadruplex Reveal a Mechanism of Ligand Conformation Adjustment for G4-Recognition. Nucleic Acids Res. 2019, 47(22), 11931-11942. DOI: 10.1093/nar/gkz1015.
- W. Liu, Y.-F. Zhong, L.-Y. Liu, C.-T. Shen, W. Zeng, F. Wang, D. Yang*, Z.-W. Mao*, Solution Structures of Multiple G-quadruplex Complexes Induced by a Platinum(II)-Based Tripod Reveal Dynamic Binding. Nat. Commun. 2018, 9(1), 3496. DOI: 10.1038/s41467-018-05810-4.