基本情况
姓名：杨立群
性别：女
出生年月：1969-08
籍贯： 云南昆明
职位：副教授，硕士生导师
联系方式
通讯地址：广州市番禺区大学城外环东路132号线上赌博app-赌博软件下载
邮编：510006
教育经历
1987.9—1994.6 武汉大学化学系高分子化学与物理专业学习, 获理学学士、硕士学位
1994.9—1997.6 中山大学高分子研究所高分子化学与物理专业学习, 获理学博士学位
2000.3—2004.3 National Institute of Advanced Industrial Science and Technology in Japan（AIST)，日本学术振兴会(JSPS)博士后和AIST博士后
工作经历
1997.7—2000.2 广州市轻工研究所，工程师；
2004.4—今 线上赌博app-赌博软件下载 高分子研究所，副教授
科研方向
天然高分子与生物高分子及其功能材料
科研项目
作为项目负责人承担的科研项目：
(1) 广东省基础与应用基础研究基金-面上项目（2024A1515013275）：3D海绵状纳米金（或银）/阳离子超支化聚合物柔性复合材料及其在酶表面增强拉曼光谱中的应用研究，2024.01-2026.12
(2) 产学研横向项目：生物基材水凝胶敷料的研发，2022.01-2025.12
(3) 广东省自然科学基金重点项目（2017B030311007）：茶多糖对血糖调控酶活性的影响及其作用机制研究，2017.05-2021.05
(4)广东省公益研究与能力建设专项（2016A020222017）：两亲性壳聚糖衍生物复合纳米粒的制备及其智能调控胰岛素释放的研究，2016.1-2018.12
(5)广州市科技计划项目（201607010249）：小肠靶向高效吸收的多糖载药纳米粒研究，2016.4-2019.3
(6) 国家自然科学基金专项基金项目（科学部主任基金）（21244005）：超支化茶多糖化学改性用作胰岛素基因转染载体的研究，2013.1-2013.12
(7) 国家自然科学基金面上项目（20974130）：基于“树枝”状两亲性支链淀粉衍生物的单分子反胶束研究，2010.1-2012.12
(8) 国家自然科学基金面上项目（20574089）：新型两亲性直链淀粉衍生物的合成及其胶束化行为，2006.1-2008.12
(9) 霍英东教育基金第十届高等院校青年教师优选资助课题基金（104036）：茶多糖对预防心脏性猝死的保健功效，2006.3-2009.2
获奖情况
获得的学术奖励：
(1) 邓宇斌，万勇，刘少喻，陈宁宁，魏富鑫，杨军林，杨立群，张黎明，何志捷，王乐.脊髓损伤修复新疗法的研究及术中电生理检测的应用，2019年3月获得广东省科学技术奖二等奖
(2) 张黎明，杨立群，易菊珍，赵三平，王冠海，梁媛媛，马栋，李玮. 生物资源大分子功能化利用的基础研究，2010年11月获得广东省科学技术奖（基础研究类）二等奖
(3) 张俐娜，许小娟，杨立群，丁琼，张玫. 复杂多糖的分子量和链构象及其对功能和性能的影响，2005年12月获得湖北省科学技术奖（自然科学类）一等奖
获得的教学奖励：
(1) 杨立群，阮文红，章明秋，朱芳.《高分子结构与性能的现代测试技术》教材的建设，2024年12月获得广东省学位与研究生教育学会优秀教学成果奖二等奖
(2) 杨立群，李谷，符若文，阮文红，梁晖.《高分子物理》课程建设，2022年6月获得中山大学线下一流本科课程
主要论著（近10年）
(1) Yingxin Wu, Kainan Hong, Juzhen Yi, Juncheng Shen, Liqun Yang*. Surface-enhanced Raman spectroscopy based on enzyme–substrate specificity for structural analyses of α-amylase and β-amylase. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 331, 125787.
(2) Juncheng Shen, Yingxin Wu, Juzhen Yi, Kainan Hong, Lin Yin, Xinye Ma, Liqun Yang*. Silver Nanoparticles-Loaded Cross-linking Branched Polyethyleneimine as a Spongy Flexible Substrate for Surface-Enhanced Raman Spectroscopy. ACS Applied Polymer Materials, 2024, 6, 7113−7123.
(3) Juncheng Shen, Yingxin Wu, Juzhen Yi, Kainan Hong, Lin Yin, Xinye Ma, Liqun Yang*. One-step synthesis of a spongy flexible substrate for surface enhanced Raman spectroscopy comprising a silver nanoparticles-loaded poly(amidoamine) dendrimer crosslinked with glutaraldehyde. Journal of Polymer Science, 2024, 62, 4377-4387.
(4) Lin Yin, Juncheng Shen, Liqun Yang*, Application of nuclear magnetic resonance spectroscopy for studying protein three-dimensional structure, Progress in Biochemistry and Biophysics, 2022, 49, 1273-1290.
(5) Juzhen Yi, Kunhua Lin, Hao Wu, Xuhong Mao, Li-Ming Zhang, Liqun Yang*. Smart controlled release of acarbose from glucose-sensitive hydrogels comprising covalently modified carboxylated pullulan and concanavalin A, Journal of Applied Polymer Science, 2021, 138, e51553.
(6) Lin Yin, Shanshan Fu, Roujun Wu, Shuyue Wei, Juzhen Yi, Li-Ming Zhang, Liqun Yang*. Chain conformation of an acidic polysaccharide from green tea and related mechanism of α-amylase inhibitory activity. International Journal of Biological Macromolecules, 2020, 164, 1124-1132.
(7) Lin Yin, Shanshan Fu, Roujun Wu, Shuyue Wei, Juzhen Yi, Li-Ming Zhang, Liqun Yang*. A neutral polysaccharide from green tea: Structure, effect on α-amylase activity and hydrolysis property. Archives of Biochemistry and Biophysics, 2020, 687, 108369.
(8) Yaqing Huang, Weihong Guo, Junzhao Zhang, Xiao Peng, Guoxin Li*, Li-Ming Zhang*, Liqun Yang*. Thermosensitive hydrogels based on methylcellulose derivatives for prevention of postoperative adhesion. Cellulose, 2020, 27, 1555–1571.
(9) Siyuan Li, Lin Yin, Juzhen Yi, Li-Ming Zhang*, Liqun Yang*. Insight into interaction mechanism between theaflavin-3-gallate and α-glucosidase using spectroscopy and molecular docking analysis. Journal of Food Biochemistry, 2021, 45, e13550.
(10) Biyun Lan, Junfeng Wu, Na Li, Chenglin Pan, Li Yan, Chuan Yang, Li-Ming Zhang*, Liqun Yang*, Meng Ren*. Hyperbranched cationic polysaccharide derivatives for efficient siRNA delivery and diabetic wound healing enhancement. International Journal of Biological Macromolecules, 2020, 154, 855-865.
(11) Na Li1, Liqun Yang1, Chenglin Pan1, Phei Er Saw, Meng Ren, Biyun Lan, Junfeng Wu, Xiaoyi Wang, Tingting Zeng, Liyan Zhou, Li-Ming Zhang*, Chuan Yang*, Li Yan*. Naturally-occurring bacterial cellulose-hyperbranched cationic polysaccharide derivative/MMP-9 siRNA composite dressing for wound healing enhancement in diabetic rats. Acta Biomaterialia, 2020, 102, 298-314.
(12) Kunhua Lin, Juzhen Yi*, Xuhong Mao, Hao Wu, Li-Ming Zhang, Liqun Yang*. Glucose-sensitive hydrogels from covalently modified carboxylated pullulan and concanavalin A for smart controlled release of insulin. Reactive and Functional Polymers, 2019, 139, 112-119.
(13) Shuyun Wu, Na Li, Chuan Yang, Li Yan, Xuan Liang, Meng Ren*, Liqun Yang*. Synthesis of cationic branched tea polysaccharide derivatives for targeted delivery of siRNA to hepatocytes. International Journal of Biological Macromolecules, 2018, 118, 808-815.
(14) Jiayun Tan, Xiaojuan Wang, Zhong Yu, Jiahao Luo, Biyun Lan, Na Li, Yachuan Xin, Chunlian Zeng, Li Yan, Li-Ming Zhang, Xiaohong Chen, Shanyue Guan, Wei Li*, Liqun Yang*. Spectroscopic investigation of a hyperbranched cationic amylopectin derivative as a multi-guest molecular host for targeted delivery of a photosensitizer to pancreatic cancer cells. Carbohydrate Polymers, 2018, 197, 38-46.
(15) Minghua Lai, Jingnan Wang, Jiayun Tan, Jiahao Luo, Li-Ming Zhang, David Y. B. Deng,*Liqun Yang*.Preparation, complexation mechanism and properties of nano-complexes of Astragalus polysaccharide and amphiphilic chitosan derivatives.Carbohydrate Polymers, 2017, 161, 261–269.
(16) Shuyun Wu, Minghua Lai, Jiahao Luo, Jingwen Pan, Li-Ming Zhang, Liqun Yang*. Interactions between α-amylase and an acidic branched polysaccharide from green tea. International Journal of Biological Macromolecules, 2017, 94, 669–678.
(17) Zhenzhen Liu, Haijun Gong, Rui Zeng, Xuan Liang, Li-Ming Zhang, Liqun Yang*, Yuqing Lan.* Efficient delivery of NF-КB siRNA to human retinal pigment epithelial cells with hyperbranched cationic polysaccharide derivative-based nanoparticles. International Journal of Nanomedicine, 2015, 10, 2735-2749.
(18) Huajie Li, Zhong Yu, Shuangping Wang, Xi Long, Li-Ming Zhang, Zhaohua Zhu, Liqun Yang*. Photosensitizer-encapsulated amphiphilic chitosan derivative micelles: Photoactivity and enhancement of phototoxicity against human pancreatic cancer cells. Journal of Photochemistry and Photobiology B: Biology, 2015, 142, 212-219.
(19) Xuan Liang, Shuyun Wu, Xianyue Ren, Daping Quan, Li-Ming Zhang, Yubing Deng, Liqun Yang.* Complexation behaviors of hyperbranched cationic glycogen derivatives with plasmid DNA revealed by resonance light scattering and circular dichroism spectroscopy. Starch-Starke, 2015, 67, 838–845.
(20) Huajie Li, Zhong Yu, Shuangping Wang, Li-Ming Zhang, Liqun Yang*. Protection of photoactivity of photosensitizers by amphiphilic polysaccharide micelles. Chinese Journal of Polymer Science, 2014, 32, 1413–1418.
(21) Zhong Yu, Huajie Li, Li-Ming Zhang, Zhaohua Zhu, Liqun Yang*. Enhancement of phototoxicity against human pancreatic cancer cells with photosensitizer-encapsulated amphiphilic sodium alginate derivative nanoparticles. International Journal of Pharmaceutics, 2014, 473, 501–509.
(22) Xuan Liang, Xianyue Ren, Zhenzhen Liu, Yingliang Liu, Jue Wang, Jingnan Wang, Li-Ming Zhang, David Y. B. Deng*, Daping Quan, Liqun Yang*. An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives. International Journal of Nanomedicine, 2014, 9, 419–435.
授权的发明专利（近10年）
(1) 杨立群*，申峻丞，马馨叶，赵青，尹林. 一种柔性的用于蛋白质表面增强拉曼光谱的阳离子超支化聚合物/贵金属纳米粒复合材料. 专利授权号：ZL 20211106926.6，授权时间：2022-08-19.
(2) 杨立群*，彭枭，黄雅清，易菊珍. 一种温敏型大孔生物水凝胶及其制备方法和应用.专利授权号：ZL 202011097216.6，授权时间：2022-11-01.
(3) 杨立群*，尹林，吴柔君，魏书玥，罗嘉浩. 一种检测α-葡萄糖苷酶活性的方法.专利授权号：ZL 201910808644.6，授权时间：2021-02-19.
(4)杨立群*，林坤华，易菊珍*，李春龙，毛旭宏，江桂生. 一种含有胆固醇和植物凝集素基团的两亲性多糖衍生物及其制备方法和应用. 专利授权号：ZL 201910092225.7，授权时间：2022-03-04.
(5)杨立群*，毛旭宏，邓宇斌，龙玲俐，林坤华，张黎明. 一种小肠靶向吸收、生物降解的糖原衍生物、其制备方法及其负载茶多糖的纳米粒. 专利授权号：ZL 201811006436.6，授权时间：2021-07-16.
(6) 杨立群*，严励*，潘成林，李娜，杨川，张黎明，吴俊凤，任萌. 一种具有RNA干扰功能的微生物纤维素复合敷料及其制备方法和应用. 专利授权号：ZL 201810517362.6，授权时间：2021-07-16.
(7) 林坤华，易菊珍*，杨立群*，吴昊. 一种智能调控胰岛素释放的植物凝集素-多糖水凝胶及其制备和应用，授权号：ZL 201710612823.2，授权日：2021-04-02.
(8) 吴燕琳，罗嘉浩，白冰，杨立群*，张黎明. 一种含多肽靶向因子的多糖衍生物及其制备方法，专利授权号：ZL 201611073567.7，授权时间：2020-05-20.
(9) 罗嘉浩，杨立群*，于钟，黎悦，张黎明. 一种阳离子超支化多糖衍生物及其在增强血卟啉类光敏剂对肿瘤细胞光毒性方面的应用，专利授权号：ZL 201610314913.X，授权时间：2019-03-28.
(10)杨立群*，赖欣宜，胡亦清，龙茜，罗嘉浩，冯子乐，张黎明. 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法，专利授权号：ZL 201510133260.0，授权时间：2019-02-01.
(11) 杨立群*，邓宇斌，谭家运，王竞男，黄玲玉，王双萍，张黎明. 小肠靶向吸收的壳聚糖衍生物、其制备方法及载药纳米粒，专利授权号：ZL201410226073.2，授权时间：2017-04-19.
(12) 杨立群*，伍淑韵，梁玄，邹珊珊，潘靖雯，吴燕琳，张黎明. 茶多糖衍生物及其制备方法，专利授权号：ZL 201310662617.5，授权时间：2015-11-18.
