基本情况 

姓名：曹乾 (CAO Qian)

性别：女

出生年月：1982-12

籍贯：河南郑州

职位：副教授，博士生导师（化学生物学）

ORCID：orcid.org/0000-0002-2040-2942

 

联系方式

通讯地址：广州市大学城外环东路132号化学材料综合楼

电子邮件：[email protected]

 

教育经历

2000.09 - 2004.07   中山大学生物科学专业，学士学位

2004.09 - 2005.12   英国诺丁汉大学应用分子微生物专业，硕士学位

2006.04 - 2010.07   英国诺丁汉大学无机化学专业，博士学位

 

工作经历 

2011.01 - 2013.09   芬兰赫尔辛基大学化学系，博士后

2013.09 - 至今        线上赌博app-赌博软件下载 ，讲师，副教授，博士生导师

 

讲授课程 

波谱解析 （全英，2+2专业），波谱解析，基础化学实验（无机），无机化学实验，有机化学实验，大学化学实验III。

 

科研方向 

生物无机化学，金属基抗肿瘤药物、诊断试剂及纳米载药体系

 

科研项目

主持了包括国家自然科学基金面上项目、青年项目，广东省自然科学基金面上项目、广州市科技计划项目、中央高校基本业务费等，参与了国家自然科学基金重点项目、国家重点研发计划。

 

获奖情况

2014 .11，中山大学“芙兰奖”(排名第6)

 

专利一览

  1. 曹乾，方浩吉，杨靖，毛宗万，黄华珍。一种环金属铱二甲双胍配合物及其制备方法和应用。专利号：202010286209.4（已授权）。
  2. 毛宗万，周丹捷，杨刚刚，潘正银，曹乾，黄华珍。一种碳酸酐酶靶向的四价铂配合物及其制备方法和应用。专利号：201910464269.8（已授权）。
  3. 毛宗万，钟毅芳，张航，黄华珍，曹乾。 一种具有双光子吸收特性的铂配合物及其制备方法和应用。专利号：201710591967.5（已授权）。

 

代表性论著

    1. X. Su, B. Liu, W. J. Wang, K. Peng, B. B. Liang, Y. Zheng, Q. Cao*, H. Zhang, B. Liu, Y. Y. Ling, X. T. Zhou and Z.-W. Mao*. Disruption of Zinc Homeostasis by A Novel Platinum(IV)-Terthiophene Complex for Anti-Tumor Immunity. Angew. Chem. Int. Ed. 2022, e202216917.
    2. X. Su, W. J. Wang, Q. Cao*, H. Zhang, B. Liu, Y. Y. Ling, X. T. Zhou and Z.-W. Mao*. A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity. Angew. Chem. Int. Ed. 2022, 61(8), e202115800. VIP论文, 内封底.
    3. Q. Cao#, D-J. Zhou#, Z-Y. Pan#, G-G. Yang, H. Zhang, L.-N. Ji and Z.-W. Mao*. CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors. Angew. Chem. Int. Ed. 2020, 59, 18556-18562.
    4. G-G. Yang, D-J. Zhou, Z-Y. Pan, J. Yang, Q. Cao*, J. Yang, D-Y, Zhang, L.-N. Ji and Z.-W. Mao*. Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities. Biomaterials, 2019, 216, 119280.
    5. G-G. Yang, H. Zhang, D-D. Yang, Q. Cao*, J. Yang, L.-N. Ji and Z.-W. Mao*. Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo. Biomaterials, 2018, 185, 73–85.
    6. J. Yang, Q. Cao*, H. Zhang, L. Hao, Zhou, Z-J Gan, Z-W. Li.; Y.-X. Tong, L.-N. Ji, and Z.-Wan Mao*. Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate. Biomaterials, 2018, 176, 94-105.
    7. G-G. Yang, X-X. Su, B-B. Liang, Z-Y. Pan, Q. Cao*, and Z.-W. Mao*. Platinum-Ruthenium Hybrid Prodrug with Multi-enzymatic Activities for Chemo-Catalytic Therapy of Hypoxic Tumors. Chemical Science, 2022, DOI: 10.1039/D2SC03375E.
    8. K-N. Wang, Q. Cao*, L-Y. Liu, Z-J. Zhao, W-T. Liu, D-J. Zhou, C-P. Tan, W. Xia, L.-N. Ji and Z.-W. Mao*Charge-Driven Tripod Somersault on DNA for Ratiometric Fluorescence Imaging of Small Molecules in Nucleus. Chemical Science 2019, 10, 10053 – 10064.
    9. G-G. Yang#, Z-Y. Pan#, D-Y, Zhang, Q. Cao*, L.-N. Ji and Z.-W. Mao*. Precisely-assembled Nanoparticles Against Cisplatin-Resistance via Cancer-specific Targeting of Mitochondria and Imaging Guided Chemo-Photothermal Therapy. ACS Appl. Mater. Interfaces, 2020, 12, 43444-43455.
    10. G-G. Yang, L. Hao, Q. Cao*, H. Zhang, J. Yang, L.-N. Ji and Z.-W. Mao*. Three-in-One Self-assembled Nanocarrier for Dual-Drug Delivery, Two-Photon Imaging, and Chemo-Photodynamic Synergistic Therapy. ACS Appl. Mater. Interfaces, 2018, 10, 28301–28313.
    11. J. Yang#, J-X, Zhao#, Q. Cao*, L, Hao, D-X, Zhou, Z-J Gan, L.-N. Ji, and Z.-Wan Mao*. Simultaneously Inducing and Tracking Cancer Cell Metabolism Repression by Mitochondria-Immobilized Rhenium(I) Complex. ACS Appl. Mater. Interfaces, 2017, 9, 13900–13912.
    12. J. Yang#, H-J. Fang#, Q. Cao* and Z.-W. Mao*. Design of Cyclometalated Iridium(III)-Metformin Complexes for Hypoxic Cancer Treatment. Chem. Comm. 2021, 57, 1093-1096. 封面论文
    13. Q. Cao#, J. Yang#, H. Zhang, L, Hao, G-G. Yang, L.-N. Ji, and Z.-Wan Mao*. Traceable In-cell Synthesis and Cytoplasm-to-Nucleus Translocation of A Schiff base Zinc Complex as A Simple and Economical Anticancer Strategy. Chem. Comm. 2019, 55, 7852 – 7855.  
    14. J. Yang, L-L. Sun, L, Hao, G-G. Yang, Z-C. Zou, Q. Cao*, L.-N. Ji, and Z.-Wan Mao*. A halogen ion-selective phosphorescence turn-on probe based on induction of Pt–Pt interactions. Chem. Comm. 2019, 55, 11191 – 11194.
    15. J. Yang, Q. Cao*, L, Hao, W-L. Hu, G-G. Yang, L.-N. Ji, and Z.-Wan Mao*. A Self-Assessed Photosensitizer: Inducing and Dual-Modal Phosphorescence Imaging of Mitochondria Oxidative stress. Chem. Comm. 2018, 54, 271–274.
    16. Q. Cao, Y. Li, E. Freisinger, P. Z. Qin,* R. K. O. Sigel,* and Z.-W Mao*. G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs. Inorg. Chem. Front. 2017, 4, 10-32. ESI高被引论文
    17. X.-H. Zheng, G. Mu, Y.-F. Zhong, T.-P. Zhang, Q. Cao*, L.-N. Ji, Y. Zhao and Z.-W. Mao*. Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction. Chem. Comm. 2016, 52, 14101-14104.
    18. J. Yang, Q. Cao*, W-L. Hu, R-R Ye, L. He, L.-N. Ji, Peter Z. Qin and Z.-Wan Mao*. Theranostic TEMPO-functionalized Ru(II) complexes as photosensitizers and oxidative stress indicators. Dalton Trans. 2017, 46, 445-454.
    19. M. Hu, J. Zhao, X. Ai, M. Budanovic, J. Mu, R. D. Webster, Q. Cao*, Z.-W Mao* and B.G. Xing*. Near infrared light-mediated photoactivation of cytotoxic Re(I) complex by lanthanide-doped upconversion nanoparticles. Dalton Trans. 2016, 45, 14101-14108.
    20. X.-H. Zheng#, Q. Cao#, Y.-L. Ding, Y.-F. Zhong, G. Mu, P. Z. Qin, L.-N. Ji, Z.-W. Mao*. Platinum(II) clovers targeting G-quadruplexes and their anticancer activities. Dalton Trans. 2015, 44, 50-53.
    21. Q. Cao, N. Andrijchenko, A. Ermilov, M. Räsänen, A. V. Nemukhin, L. Khriachtchev*. Interaction of Aromatic Compounds with Xenon: Spectroscopic and Computational Characterization for the Cases of p-creosl and Toluene. J. Phys. Chem. A 2015, 119 (11), 2587–2593.
    22. Q. Cao, G. Y. Gor, K. Krogh-Jespersen, L. Khriachtchev*. Non-covalent interaction of nitrous oxide with aromatic compounds: Spectroscopic and computational evidence for the formation of 1:1 complexes. J. Chem. Phys. 2014, 140, 144304.
    23. Q. Cao, S. Berski, M. Räsänen, Z. Latajka, L. Khriachtchev*. Reaction of atomic hydrogen with formic acid. Phys. Chem. Chem. Phys. 2014, 16, 5993-6001.
    24. Q. Cao, S. Berski, M. Räsänen, Z. Latajka, L. Khriachtchev*. Spectroscopic and computational characterization of the HCO...H2O complex. J. Phys. Chem. A 2013, 117, 4385-4393.
    25. Q. Cao, N. Andrijchenko, A.-E. Ahola, A. V. Domanskaya, M. Räsänen, A. Ermilov, A. V. Nemukhin, L. Khriachtchev*. Interaction of Phenol with Xenon and Nitrogen: Spectroscopic and Computational Characterization. J. Chem. Phys. 2012, 137, 134305.
    26. Q. Cao, M. Melavuori, J. Lundell, M. Räsänen, L. Khriachtchev*. Matrix-isolation and ab initio study of the complex between formic acid and xenon. J. Mol. Struct. 2012, 1025, 132.
    27. Q. Cao, C. M. Creely, E. S. Davies, J. Dyer, T. Easun, D. C. Grills, D. A. McGovern, J. McMaster, J. Pitchford, J. A. Smith, X.-Z. Sun, J. M. Kelly, M. W. George*. Excited state Dependent Electron Transfer of Re-dppz Intercalator in DNA: A time-resolved UV-Visible and IR Absorption Investigation into the Photophysics of fac-[Re(CO)3(dppz-F2)(py)]+ Bound to Either [poly(dA-dT)]2 or [poly(dG-dC)]2. Photochem. Photobiol. Sci. 2011, 10, 1355-1364.
    28. Q. Cao#, X. Guan#, M. W. George*, D. L. Phillips*, C. Ma, W. M. Kwok, M. Li, Y. Du, X.-Z. Sun, J. Xue. Ultrafast time-resolved infrared and resonance Raman spectroscopic study of the photo-deprotection and rearrangement reactions of p-hydroxyphenacyl caged phosphates. Faraday Discuss. 2010, 145, 171-183.